Late MRD response determines relapse risk overall and in subsets of childhood T-cell ALL: results of the AIEOP-BFM-ALL 2000 study

Schrappe, Martin; Grazia Valsecchi, Maria; R. Bartram, Claus; Schrauder, André; Panzer-Grümayer, Renate; Möricke, Anja; Parasole, Rosanna; Zimmermann, Martin; Dworzak, Michael; Buldini, Barbara; Reiter, Alfred; Basso, Giuseppe; Klingebiel, Thomas; Messina, Chiara; Ratei, Richard; Cazzaniga, Giovanni; Koehler, Rolf; Locatelli, Franco; W. Schäfer, Beat; Aricò, Maurizio; Welte, Karl; J.M. van Dongen, Jacques; Gadner, Helmut; Biondi, Andrea; Conter, Valentino

doi:10.1182/blood-2011-03-338707

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Late MRD response determines relapse risk overall and in subsets of childhood T-cell ALL: results of the AIEOP-BFM-ALL 2000 study

Shared by NobleBlocks on Aug 25, 2011 • 12:00 AM UTC

Authors:

Martin Schrappe

Maria Grazia Valsecchi

Claus R. Bartram

Abstract

Abstract The prognostic value of MRD in large series of childhood T-ALL has not yet been established. Trial AIEOP-BFM-ALL 2000 introduced standardized quantitative assessment of MRD for stratification, based on immunoglobulin and TCR gene rearrangements as polymerase chain reaction targets: Patients...

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