Somatic hypermutation of human mitochondrial and nuclear DNA by APOBEC3 cytidine deaminases, a pathway for DNA catabolism

Suspène, Rodolphe; Aynaud, Marie-Ming; Guétard, Denise; Henry, Michel; Eckhoff, Grace; Marchio, Agnès; Pineau, Pascal; Dejean, Anne; Vartanian, Jean‐Pierre; Wain–Hobson, Simon

doi:10.1073/pnas.1009687108

Public

Somatic hypermutation of human mitochondrial and nuclear DNA by APOBEC3 cytidine deaminases, a pathway for DNA catabolism

Published in Proceedings of the National Academy of Sciences • Mar 2, 2011

Authors:

Rodolphe Suspène

Marie-Ming Aynaud

Denise Guétard

Abstract

The human APOBEC3 (A3A-A3H) locus encodes six cytidine deaminases that edit single-stranded DNA, the result being DNA peppered with uridine. Although several cytidine deaminases are clearly restriction factors for retroviruses and hepadnaviruses, it is not known if APOBEC3 enzymes have roles outside...

Subject

Cytidine

Cytidine deaminase

Somatic hypermutation

Research Assistant

AI chat, annotations, notes & similar papers

Finding related papers...

Discussions

(0)

No comments yet

Be the first to share your thoughts!