Clinical-grade production of human mesenchymal stromal cells: occurrence of aneuploidy without transformation

Tarte, Karin; Burlaud‐Gaillard, Julien; Lataillade, Jean‐Jacques; Fouillard, L; Becker, Martine; Mossafa, Hossein; Tchirkov, Andréï; Rouard, Hélène; Henry, Cathérine; Splingard, Marie; Dulong, Joëlle; Monnier, Delphine; Gourmelon, P.; Gorin, Norbert-Claude; Sensebé, Luc; behalf of Société Française de Greffe de Moelle et Thérapie Cellulaire, on

doi:10.1182/blood-2009-05-219907

Public

Clinical-grade production of human mesenchymal stromal cells: occurrence of aneuploidy without transformation

Published in Blood • Dec 24, 2009

Authors:

Karin Tarte

Julien Burlaud‐Gaillard

Jean‐Jacques Lataillade

Abstract

Clinical-grade human mesenchymal stromal cells (MSCs) have been expanded in vitro for tissue engineering or immunoregulatory purposes without standardized culture conditions or release criteria. Although human MSCs show poor susceptibility for oncogenic transformation, 2 recent studies described the...

Subject

Mesenchymal stem cell

Aneuploidy

Cancer research

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