Role of the ENTH Domain in Phosphatidylinositol-4,5-Bisphosphate Binding and Endocytosis

Itoh, Toshiki; Koshiba, S.; Kigawa, T.; Kikuchi, Akira; Yokoyama, Shigeyuki; Takenawa, Tadaomi

doi:10.1126/science.291.5506.1047

Public

Role of the ENTH Domain in Phosphatidylinositol-4,5-Bisphosphate Binding and Endocytosis

Published in Science • Feb 9, 2001

Authors:

Toshiki Itoh

S. Koshiba

T. Kigawa

Abstract

Endocytic proteins such as epsin, AP180, and Hip1R (Sla2p) share a conserved modular region termed the epsin NH2-terminal homology (ENTH) domain, which plays a crucial role in clathrin-mediated endocytosis through an unknown target. Here, we demonstrate a strong affinity of the ENTH domain for phosp...

Subject

Endocytosis

Pleckstrin homology domain

Cell biology

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