Role of the ENTH domain in phosphatidylinositol-4,5-bisphosphate binding and endocytosis.

T, Itoh; S, Koshiba; T, Kigawa; A, Kikuchi; S, Yokoyama; T, Takenawa

doi:10.1126/science.291.5506.1047

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Role of the ENTH domain in phosphatidylinositol-4,5-bisphosphate binding and endocytosis.

Shared by NobleBlocks on Feb 1, 2001 • 12:00 AM UTC

Authors:

Itoh T

Koshiba S

Kigawa T

Abstract

Endocytic proteins such as epsin, AP180, and Hip1R (Sla2p) share a conserved modular region termed the epsin NH2-terminal homology (ENTH) domain, which plays a crucial role in clathrin-mediated endocytosis through an unknown target. Here, we demonstrate a strong affinity of the ENTH domain for phosp...

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