Fumaric acid esters exert neuroprotective effects in neuroinflammation via activation of the Nrf2 antioxidant pathway

A. Linker, Ralf; Lee, De-Hyung; Ryan, Sarah; Marie Van Dam, Anne; Conrad, Rebecca; Bista, Pradeep; Zeng, Weike; Hronowsky, Xiaoping; Buko, Alex; Chollate, Sowmya; Ellrichmann, Gisa; Brück, Wolfgang; P. DAWSON, K.; Goelz, Susan; Wiese, Stefan; H. Scannevin, Robert; Lukashev, Matvey; Gold, Ralf

doi:10.1093/brain/awq386

Public

Fumaric acid esters exert neuroprotective effects in neuroinflammation via activation of the Nrf2 antioxidant pathway

Published in Brain • Feb 22, 2011

Authors:

Ralf A. Linker

De-Hyung Lee

Sarah Ryan

Abstract

Inflammation and oxidative stress are thought to promote tissue damage in multiple sclerosis. Thus, novel therapeutics enhancing cellular resistance to free radicals could prove useful for multiple sclerosis treatment. BG00012 is an oral formulation of dimethylfumarate. In a phase II multiple sclero...

Subject

Dimethyl fumarate

Experimental autoimmune encephalomyelitis

Multiple sclerosis

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