Microglia Protect Neurons against Ischemia by Synthesis of Tumor Necrosis Factor

Lykke Lambertsen, Kate; Hjelm Clausen, Bettina; A. Babcock, Alicia; Gregersen, Rikke; Fenger, Christina; Hvilsted Nielsen, Helle; Skov Haugaard, Laila; Wirenfeldt, Martin; Nielsen, Marianne; Dagnæs‐Hansen, Frederik; Bluethmann, Horst; J. Færgeman, Nils; Meldgaard, Michael; Deierborg, Tomas; Finsen, Bente

doi:10.1523/jneurosci.5505-08.2009

Public

Microglia Protect Neurons against Ischemia by Synthesis of Tumor Necrosis Factor

Published in Journal of Neuroscience • Feb 4, 2009

Authors:

Kate Lykke Lambertsen

Bettina Hjelm Clausen

Alicia A. Babcock

Abstract

Microglia and infiltrating leukocytes are considered major producers of tumor necrosis factor (TNF), which is a crucial player in cerebral ischemia and brain inflammation. We have identified a neuroprotective role for microglial-derived TNF in cerebral ischemia in mice. We show that cortical infarct...

Subject

Microglia

Neuroprotection

Tumor necrosis factor alpha

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