The Reward Deficiency Syndrome: A Biogenetic Model for the Diagnosis and Treatment of Impulsive, Addictive and Compulsive Behaviors

Blum, Kenneth; R. Braverman, Eric; M. Holder, Jay; F. Lubar, Joel; J. Monastra, Vincent; Miller, David; O. Lubar, Judith; J.H. Chen, Thomas; E. Comings, David

doi:10.1080/02791072.2000.10736099

Public

The Reward Deficiency Syndrome: A Biogenetic Model for the Diagnosis and Treatment of Impulsive, Addictive and Compulsive Behaviors

Published in Journal of Psychoactive Drugs • Nov 1, 2000

Authors:

Kenneth Blum

Eric R. Braverman

Jay M. Holder

Abstract

The dopaminergic system, and in particular the dopamine D2 receptor, has been implicated in reward mechanisms. The net effect of neurotransmitter interaction at the mesolimbic brain region induces "reward" when dopamine (DA) is released from the neuron at the nucleus accumbens and interacts with a d...

Subject

Nucleus accumbens

Dopamine

Reward system

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