Pravastatin Treatment Increases Collagen Content and Decreases Lipid Content, Inflammation, Metalloproteinases, and Cell Death in Human Carotid Plaques

Crisby, Milita; Nordin-Fredriksson, Gunilla; K. Shah, Prediman; Yano, Juliana; Zhu, Jenny; Nilsson, Jan

doi:10.1161/01.cir.103.7.926

Public

Pravastatin Treatment Increases Collagen Content and Decreases Lipid Content, Inflammation, Metalloproteinases, and Cell Death in Human Carotid Plaques

Published in Circulation • Feb 20, 2001

Authors:

Milita Crisby

Gunilla Nordin-Fredriksson

Prediman K. Shah

Abstract

BACKGROUND: The clinical benefits of lipid lowering with statins are attributed to changes in plaque composition leading to lesion stability, but supporting clinical data from human studies are lacking. Therefore, we investigated the effect of 3 months of pravastatin treatment on composition of huma...

Subject

Medicine

Carotid endarterectomy

Pravastatin

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