<i>In vivo</i> evidence that erythropoietin protects neurons from ischemic damage

Sakanaka, Masahiro; Wen, Tong‐Chun; Matsuda, Seiji; Masuda, Seiji; Morishita, Emi; Nagao, Masaya; Sasaki, Ryuzo

doi:10.1073/pnas.95.8.4635

Public

In vivo evidence that erythropoietin protects neurons from ischemic damage

Published in Proceedings of the National Academy of Sciences • Apr 14, 1998

Authors:

Masahiro Sakanaka

Tong‐Chun Wen

Seiji Matsuda

Abstract

Erythropoietin (EPO) produced by the kidney and the liver (in fetuses) stimulates erythropoiesis. In the central nervous system, neurons express EPO receptor (EPOR) and astrocytes produce EPO. EPO has been shown to protect primary cultured neurons from N-methyl-D-aspartate (NMDA) receptor-mediated g...

Subject

Erythropoietin receptor

Neuroprotection

Erythropoietin

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