Disease duration and the integrity of the nigrostriatal system in Parkinson’s disease

H. Kordower, Jeffrey; Warren Olanow, C.; B. Dodiya, Hemraj; Chu, Yaping; G. Beach, Thomas; H. Adler, Charles; M. Halliday, Glenda; T. Bartus, Raymond

doi:10.1093/brain/awt192

Public

Disease duration and the integrity of the nigrostriatal system in Parkinson’s disease

Published in Brain • Jul 23, 2013

Authors:

Jeffrey H. Kordower

C. Warren Olanow

Hemraj B. Dodiya

Abstract

The pace of nigrostriatal degeneration, both with regards to striatal denervation and loss of melanin and tyrosine hydroxylase-positive neurons, is poorly understood especially early in the Parkinson's disease process. This study investigated the extent of nigrostriatal degeneration in patients with...

Subject

Pars compacta

Substantia nigra

Tyrosine hydroxylase

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