Flip and Flop: A Cell-Specific Functional Switch in Glutamate-Operated Channels of the CNS

Sommer, Bernd; Keinänen, Kari; A. Verdoorn, Todd; Wisden, William; Burnashev, Nail; Herb, Anne; Köhler, Martin; Takagi, Tamaki; Sakmann, Bert; H. Seeburg, Peter

doi:10.1126/science.1699275

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Flip and Flop: A Cell-Specific Functional Switch in Glutamate-Operated Channels of the CNS

Published in Science • Sep 28, 1990

Authors:

Bernd Sommer

Kari Keinänen

Todd A. Verdoorn

Abstract

In the central nervous system (CNS), the principal mediators of fast synaptic excitatory neurotransmission are L-glutamate-gated ion channels that are responsive to the glutamate agonist alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionic acid (AMPA). In each member of a family of four abundant AMP...

Subject

AMPA receptor

Kainate receptor

Glutamate receptor

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