Epitope mapping of ADAMTS13 autoantibodies in acquired thrombotic thrombocytopenic purpura

Klaus, Christoph; Plaimauer, Barbara; Studt, Jan–Dirk; Dorner, Friedrich; Lämmle, Bernhard; Mannuccio Mannucci, Pier; Scheiflinger, Friedrich

doi:10.1182/blood-2003-12-4165

Public

Epitope mapping of ADAMTS13 autoantibodies in acquired thrombotic thrombocytopenic purpura

Published in Blood • Feb 24, 2004

Authors:

Christoph Klaus

Barbara Plaimauer

Jan–Dirk Studt

Abstract

Severe deficiency of the von Willebrand factor (VWF)-cleaving protease ADAMTS13 can lead to thrombotic thrombocytopenic purpura (TTP), a disease associated with the widespread formation of platelet-rich thrombi in many organs. Autoantibodies that inactivate ADAMTS13 are the most frequent cause of ac...

Subject

ADAMTS13

Thrombotic thrombocytopenic purpura

Autoantibody

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