Cutting Edge: Toll-Like Receptor 4 (TLR4)-Deficient Mice Are Hyporesponsive to Lipopolysaccharide: Evidence for TLR4 as the <i>Lps</i> Gene Product

Hoshino, Katsuaki; Takeuchi, Osamu; Kawai, Taro; Sanjo, Hideki; Ogawa, Tomohiko; Takeda, Yoshifumi; Takeda, Kiyoshi; Akira, Shizuo

doi:10.4049/jimmunol.162.7.3749

Public

Cutting Edge: Toll-Like Receptor 4 (TLR4)-Deficient Mice Are Hyporesponsive to Lipopolysaccharide: Evidence for TLR4 as the Lps Gene Product

Published in The Journal of Immunology • Apr 1, 1999

Authors:

Katsuaki Hoshino

Osamu Takeuchi

Taro Kawai

Abstract

The human homologue of Drosophila Toll (hToll), also called Toll-like receptor 4 (TLR4), is a recently cloned receptor of the IL-1/Toll receptor family. Interestingly, the TLR4 gene has been localized to the same region to which the Lps locus (endotoxin unresponsive gene locus) is mapped. To examine...

Subject

TLR4

Toll-like receptor

Receptor

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