The IL23R R381Q Gene Variant Protects against Immune-Mediated Diseases by Impairing IL-23-Induced Th17 Effector Response in Humans

Di Meglio, Paola; Di Cesare, Antonella; Laggner, Ute; Chu, Chung-Ching; Napolitano, L; Villanova, Federica; Tosi, Isabella; Capon, Francesca; C. Trembath, Richard; Peris, Ketty; O. Nestlé, Frank

doi:10.1371/journal.pone.0017160

Public

The IL23R R381Q Gene Variant Protects against Immune-Mediated Diseases by Impairing IL-23-Induced Th17 Effector Response in Humans

Published in PLoS ONE • Feb 22, 2011

Authors:

Paola Di Meglio

Antonella Di Cesare

Ute Laggner

Abstract

IL-23 and Th17 cells are key players in tissue immunosurveillance and are implicated in human immune-mediated diseases. Genome-wide association studies have shown that the IL23R R381Q gene variant protects against psoriasis, Crohn's disease and ankylosing spondylitis. We investigated the immunologic...

Subject

Interleukin 23

Immunology

Immune system

Research Assistant

AI chat, annotations, notes & similar papers

Finding related papers...

Discussions

(0)

No comments yet

Be the first to share your thoughts!