Retinol-Binding Protein 4 and Insulin Resistance in Lean, Obese, and Diabetic Subjects

E. Graham, Timothy; Yang, Qin; Blüher, Matthias; Hammarstedt, Ann; P. Ciaraldi, Theodore; R. Henry, Robert; J. Wason, Christopher; Oberbach, Andreas; Jansson, Per‐Anders; Smith, Ulf; B. Kahn, Barbara

doi:10.1056/nejmoa054862

Public

Retinol-Binding Protein 4 and Insulin Resistance in Lean, Obese, and Diabetic Subjects

Published in New England Journal of Medicine • Jun 14, 2006

Authors:

Timothy E. Graham

Qin Yang

Matthias Blüher

Abstract

BACKGROUND: Insulin resistance has a causal role in type 2 diabetes. Serum levels of retinol-binding protein 4 (RBP4), a protein secreted by adipocytes, are increased in insulin-resistant states. Experiments in mice suggest that elevated RBP4 levels cause insulin resistance. We sought to determine w...

Subject

Retinol binding protein 4

Insulin resistance

Internal medicine

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