Prooxidant toxicity of polyphenolic antioxidants to HL‐60 cells: description of quantitative structure‐activity relationships

Sergedien≐, Egl≐; Jönsson, Kerstin; Szymusiak, Henryk; Tyrakowska, Bożena; M.C.M. Rietjens, Ivonne; Č≐nas, Narimantas

doi:10.1016/s0014-5793(99)01561-6

Public

Prooxidant toxicity of polyphenolic antioxidants to HL‐60 cells: description of quantitative structure‐activity relationships

Published in FEBS Letters • Nov 30, 1999

Authors:

Egl≐ Sergedien≐

Kerstin Jönsson

Henryk Szymusiak

Abstract

Polyphenolic antioxidants exhibited a dose-dependent toxicity against human promyelocytic leukemia cells (HL-60). Their action was accompanied by malondialdehyde formation, and was partly prevented by desferrioxamine and the antioxidant N,N'-diphenyl-p-phenylene diamine. This points to a prooxidant ...

Subject

Chemistry

Lipophilicity

Polyphenol

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