Regulation of Autophagy and Its Associated Cell Death by “Sphingolipid Rheostat”

Taniguchi, Makoto; Kitatani, Kazuyuki; Kondo, Tadakazu; Hashimoto‐Nishimura, Mayumi; Asano, S; Hayashi, Akira; Mitsutake, Susumu; Igarashi, Yasuyuki; Umehara, Hisanori; Takeya, Hiroyuki; Kigawa, Junzo; Okazaki, Toshiro

doi:10.1074/jbc.m112.416552

Public

Regulation of Autophagy and Its Associated Cell Death by “Sphingolipid Rheostat”

Published in Journal of Biological Chemistry • Oct 3, 2012

Authors:

Makoto Taniguchi

Kazuyuki Kitatani

Tadakazu Kondo

Abstract

The role of "sphingolipid rheostat" by ceramide and sphingosine 1-phosphate (S1P) in the regulation of autophagy remains unclear. In human leukemia HL-60 cells, amino acid deprivation (AA(-)) caused autophagy with an increase in acid sphingomyleinase (SMase) activity and ceramide, which serves as an...

Subject

Autophagy

Ceramide

Cell biology

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