Blood Stage Malaria Vaccine Eliciting High Antigen-Specific Antibody Concentrations Confers No Protection to Young Children in Western Kenya

Ogutu, Bernhards; J. Apollo, Odika; McKinney, Denise; Okoth, Willis; Siangla, Joram; Dubovsky, Filip; Tucker, Kathryn; Waitumbi, John; L. Diggs, Carter; Wittes, Janet; Malkin, Elissa; Leach, Amanda; Soisson, Lorraine; Milman, Jessica; Otieno, Lucas; A. Holland, Carolyn; E. Polhemus, Mark; Remich, Shon; F. Ockenhouse, Christian; Cohen, Joe; Ripley Ballou, W.; K. Martin, Samuel; Angov, Evelina; Ann Stewart, V.; A. Lyon, Jeffrey; Gray Heppner, D.; R. Withers, Mark; the MSP-1 Malaria Vaccine Working Group, for

doi:10.1371/journal.pone.0004708

Public

Blood Stage Malaria Vaccine Eliciting High Antigen-Specific Antibody Concentrations Confers No Protection to Young Children in Western Kenya

Published in PLoS ONE • Mar 5, 2009

Authors:

Bernhards Ogutu

Odika J. Apollo

Denise McKinney

Abstract

OBJECTIVE: The antigen, falciparum malaria protein 1 (FMP1), represents the 42-kDa C-terminal fragment of merozoite surface protein-1 (MSP-1) of the 3D7 clone of P. falciparum. Formulated with AS02 (a proprietary Adjuvant System), it constitutes the FMP1/AS02 candidate malaria vaccine. We evaluated ...

Subject

Malaria

Medicine

Immunogenicity

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