Astrocyte-induced Synaptogenesis Is Mediated by Transforming Growth Factor β Signaling through Modulation of d-Serine Levels in Cerebral Cortex Neurons

Pereira Diniz, Luan; Almeida, Juliana; Tortelli, Vanessa; Vargas Lopes, Charles; Setti-Perdigão, Pedro; Stipursky, Joice; Assad Kahn, Suzana; Romão, Luciana; De Miranda, Joari; Vieira Alves‐Leon, Soniza; Marcondes de Souza, Jorge; G. Castro, Newton; Panizzutti, Rogério; Carvalho Alcântara Gomes, Flávia

doi:10.1074/jbc.m112.380824

Public

Astrocyte-induced Synaptogenesis Is Mediated by Transforming Growth Factor β Signaling through Modulation of d-Serine Levels in Cerebral Cortex Neurons

Published in Journal of Biological Chemistry • Oct 12, 2012

Authors:

Luan Pereira Diniz

Juliana Almeida

Vanessa Tortelli

Abstract

Assembly of synapses requires proper coordination between pre- and postsynaptic elements. Identification of cellular and molecular events in synapse formation and maintenance is a key step to understand human perception, learning, memory, and cognition. A key role for astrocytes in synapse formation...

Subject

Synaptogenesis

Postsynaptic potential

Synapse

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