Genetic Modifiers of Lung Disease in Cystic Fibrosis

L. Drumm, Mitchell; W. Konstan, Michael; Schluchter, Mark; Handler, Allison; G. Pace, Rhonda; Zou, Fei; A. Zariwala, Maimoona; C. Fargo, David; Xu, Airong; M. Dunn, John; Darrah, Rebecca; Dorfman, Ruslan; J. Sandford, Andrew; Corey, Mary; Zielenski, Julian; R. Durie, Peter; A.B. Goddard, Katrina; R. Yankaskas, James; A. Wright, Fred; R. Knowles, Michael

doi:10.1056/nejmoa051469

Public

Genetic Modifiers of Lung Disease in Cystic Fibrosis

Published in New England Journal of Medicine • Oct 5, 2005

Authors:

Mitchell L. Drumm

Michael W. Konstan

Mark Schluchter

Abstract

BACKGROUND: Polymorphisms in genes other than the cystic fibrosis transmembrane conductance regulator (CFTR) gene may modify the severity of pulmonary disease in patients with cystic fibrosis. METHODS: We performed two studies with different patient samples. We first tested 808 patients who were hom...

Subject

Cystic fibrosis

Medicine

Genotype

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