Epithelial–Mesenchymal Transition Induced by TNF-α Requires NF-κB–Mediated Transcriptional Upregulation of Twist1

Li, Chia‐Wei; Xia, Weiya; Huo, Longfei; Lim, Seung-Oe; Wu, Yun; L. Hsu, Jennifer; Chao, Chi-Hong; Yamaguchi, Hirohito; Yang, Neng-Kai; Ding, Qingqing; Wang, Yan; Lai, Yun‐Ju; M. LaBaff, Adam; Wu, Ting-Jung; Lin, Been‐Ren; Yang, Muh‐Hwa; N. Hortobágyi, Gabriel; Hung, Mien‐Chie

doi:10.1158/0008-5472.can-11-3123

Public

Epithelial–Mesenchymal Transition Induced by TNF-α Requires NF-κB–Mediated Transcriptional Upregulation of Twist1

Published in Cancer Research • Jan 17, 2012

Authors:

Chia‐Wei Li

Weiya Xia

Longfei Huo

Abstract

Proinflammatory cytokines produced in the tumor microenvironment facilitate tumor development and metastatic progression. In particular, TNF-α promotes cancer invasion and angiogenesis associated with epithelial-mesenchymal transition (EMT); however, the mechanisms underlying its induction of EMT in...

Subject

Twist transcription factor

Downregulation and upregulation

Epithelial–mesenchymal transition

Research Assistant

AI chat, annotations, notes & similar papers

Finding related papers...

Discussions

(0)

No comments yet

Be the first to share your thoughts!