Central muscarinic cholinergic regulation of the systemic inflammatory response during endotoxemia

A. Pavlov, Valentin; Ochani, Mahendar; Gallowitsch‐Puerta, Margot; Ochani, Kanta; M. Huston, Jared; J. Czura, Christopher; Al‐Abed, Yousef; J. Tracey, Kevin

doi:10.1073/pnas.0600506103

Public

Central muscarinic cholinergic regulation of the systemic inflammatory response during endotoxemia

Published in Proceedings of the National Academy of Sciences • Mar 20, 2006

Authors:

Valentin A. Pavlov

Mahendar Ochani

Margot Gallowitsch‐Puerta

Abstract

TNF has a critical mediator role in inflammation and is an important therapeutic target. We recently discovered that TNF production is regulated by neural signals through the vagus nerve. Activation of this "cholinergic antiinflammatory pathway" inhibits the production of TNF and other cytokines and...

Subject

Muscarinic acetylcholine receptor

Muscarinic acetylcholine receptor M2

Methoctramine

Research Assistant

AI chat, annotations, notes & similar papers

Finding related papers...

Discussions

(0)

No comments yet

Be the first to share your thoughts!