AMG 531, a Thrombopoiesis-Stimulating Protein, for Chronic ITP

B. Bussel, James; J. Kuter, David; N. George, James; McMillan, Robert; M. Aledort, Louis; T. Conklin, George; Lichtin, Alan; M. Lyons, Roger; Nieva, Jorgé; S. Wasser, Jeffrey; Wiznitzer, Israel; Kelly, Reggie; Chen, Chien-Feng; L. Nichol, Janet

doi:10.1056/nejmoa054626

Public

AMG 531, a Thrombopoiesis-Stimulating Protein, for Chronic ITP

Published in New England Journal of Medicine • Oct 18, 2006

Authors:

James B. Bussel

David J. Kuter

James N. George

Abstract

BACKGROUND: Most current treatments for chronic immune thrombocytopenic purpura (ITP) act by decreasing platelet destruction. In a phase 1-2 study, we administered a thrombopoiesis-stimulating protein, AMG 531, to patients with ITP. METHODS: In phase 1, 24 patients who had received at least one trea...

Subject

Medicine

Thrombopoiesis

Platelet

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