Endothelial-Vasoprotective Effects of High-Density Lipoprotein Are Impaired in Patients With Type 2 Diabetes Mellitus but Are Improved After Extended-Release Niacin Therapy

Sorrentino, Sajoscha; Besler, Christian; Rohrer, Lucia; Meyer, Martin; Heinrich, Kathrin; H. Bahlmann, Ferdinand; Mueller, Maja; Horváth, Tibor; Doerries, Carola; Heinemann, Mariko; Flemmer, Stella; Markowski, Andrea; Manes, Costantina; Bähr, Mathias; Haller, Hermann; von Eckardstein, Arnold; Drexler, Helmut; Landmesser, Ulf

doi:10.1161/circulationaha.108.836346

Public

Endothelial-Vasoprotective Effects of High-Density Lipoprotein Are Impaired in Patients With Type 2 Diabetes Mellitus but Are Improved After Extended-Release Niacin Therapy

Published in Circulation • Dec 22, 2009

Authors:

Sajoscha Sorrentino

Christian Besler

Lucia Rohrer

Abstract

BACKGROUND: High-density lipoprotein (HDL)-raising therapies are currently under intense evaluation, but the effects of HDL may be highly heterogeneous. We therefore compared the endothelial effects of HDL from healthy subjects and from patients with type 2 diabetes mellitus and low HDL (meeting the...

Subject

Niacin

Medicine

Endothelial dysfunction

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