St John’s wort extract (Ze 117) does not alter the pharmacokinetics of a low-dose oral contraceptive

Will-Shahab, L; Bauer, Steffen; Kunter, Ullrich; Roots, Ivar; Brattström, A.

doi:10.1007/s00228-008-0587-2

Public

St John’s wort extract (Ze 117) does not alter the pharmacokinetics of a low-dose oral contraceptive

Published in European Journal of Clinical Pharmacology • Nov 17, 2008

Authors:

L Will-Shahab

Steffen Bauer

Ullrich Kunter

Abstract

PURPOSE: St John's wort (Hypericum perforatum) is an herbal remedy that is widely used in the treatment of depression. Recent clinical data have demonstrated that St John's wort extracts interfere with the action of various drugs and possibly also with combined oral contraceptives. Therefore, we inv...

Subject

Hypericum perforatum

Pharmacokinetics

Ethinylestradiol

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