A Gain-of-Function Mutation of <i>JAK2</i> in Myeloproliferative Disorders

Královics, Róbert; Passamonti, Francesco; Buser, Andreas; Teo, Soon-Siong; Tiedt, Ralph; Passweg, Jakob; Tichelli, André; Cazzola, Mario; C. Skoda, Radek

doi:10.1056/nejmoa051113

Public

A Gain-of-Function Mutation of JAK2 in Myeloproliferative Disorders

Published in New England Journal of Medicine • Apr 27, 2005

Authors:

Róbert Královics

Francesco Passamonti

Andreas Buser

Abstract

BACKGROUND: Polycythemia vera, essential thrombocythemia, and idiopathic myelofibrosis are clonal myeloproliferative disorders arising from a multipotent progenitor. The loss of heterozygosity (LOH) on the short arm of chromosome 9 (9pLOH) in myeloproliferative disorders suggests that 9p harbors a m...

Subject

Essential thrombocythemia

Polycythemia vera

Medicine

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