<i>In Vitro</i> Cross-Linking of Mycobacterium tuberculosis Peptidoglycan by <scp>l</scp> , <scp>d</scp> -Transpeptidases and Inactivation of These Enzymes by Carbapenems

Cordillot, Mathilde; Dubée, Vincent; Triboulet, Sébastien; Dubost, Lionel; Marie, Arul; Hugonnet, Jean‐Emmanuel; Arthur, Michel; Mainardi, Jean‐Luc

doi:10.1128/aac.01663-13

Public

In Vitro Cross-Linking of Mycobacterium tuberculosis Peptidoglycan by l , d -Transpeptidases and Inactivation of These Enzymes by Carbapenems

Published in Antimicrobial Agents and Chemotherapy • Sep 17, 2013

Authors:

Mathilde Cordillot

Vincent Dubée

Sébastien Triboulet

Abstract

The Mycobacterium tuberculosis peptidoglycan is cross-linked mainly by l,d-transpeptidases (LDTs), which are efficiently inactivated by a single β-lactam class, the carbapenems. Development of carbapenems for tuberculosis treatment has recently raised considerable interest since these drugs, in asso...

Subject

Peptidoglycan

Ertapenem

Imipenem

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