Comparison of Full Factorial Design, Central Composite Design, and Box-Behnken Design in Chromatographic Method Development for the Determination of Fluconazole and Its Impurities

Rakić, Tijana; Kasagić‐Vujanović, Irena; Jovanović, Marko; Jančić–Stojanović, Biljana; Ivanović, Darko

doi:10.1080/00032719.2013.867503

Public

Comparison of Full Factorial Design, Central Composite Design, and Box-Behnken Design in Chromatographic Method Development for the Determination of Fluconazole and Its Impurities

Published in Analytical Letters • Feb 24, 2014

Authors:

Tijana Rakić

Irena Kasagić‐Vujanović

Marko Jovanović

Abstract

This paper presents the development and optimization of a liquid chromatographic method for the determination of fluconazole and its impurities by experimental design methodology. Four experimental design types were applied: two-level full factorial design, central composite design, Box-Behnken desi...

Subject

Box–Behnken design

Factorial experiment

Central composite design

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