Suppression of adjuvant arthritis in rats by induction of oral tolerance to mycobacterial 65‐kDa heat shock protein

Azizul Haque, Md; Yoshino, Shin; Inada, Shigeyasu; Nomaguchi, Hiroko; Tokunaga, Osamu; Kohashi, Osamu

doi:10.1002/eji.1830261116

Public

Suppression of adjuvant arthritis in rats by induction of oral tolerance to mycobacterial 65‐kDa heat shock protein

Published in European Journal of Immunology • Nov 1, 1996

Authors:

Md Azizul Haque

Shin Yoshino

Shigeyasu Inada

Abstract

Oral administration of mycobacterial 65-kDa heat shock protein (HSP) given daily for 5 days prior to immunization with Mycobacterium tuberculosis (Mt) suppressed the development of adjuvant arthritis (AA) in rats. AA was significantly suppressed by 30 and 300 micrograms HSP, and variably by 0.3, 3 m...

Subject

Heat shock protein

Spleen

Biology

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