Functional and molecular biological evidence for a possible <i>β</i><sub>3</sub>‐adrenoceptor in the human detrusor muscle

Igawa, Yasuhiko; Yamazaki, Yoshinobu; Takeda, Hiroo; Hayakawa, Kohichi; Akahane, Masuo; Ajisawa, Yukiyoshi; Yoneyama, Takehisa; Nishizawa, Osamu; Andersson, Karl‐Erik

doi:10.1038/sj.bjp.0702358

Public

Functional and molecular biological evidence for a possible β3‐adrenoceptor in the human detrusor muscle

Published in British Journal of Pharmacology • Feb 1, 1999

Authors:

Yasuhiko Igawa

Yoshinobu Yamazaki

Hiroo Takeda

Abstract

The possible existence of a beta3-adrenergic receptor (beta3-AR) in the human detrusor muscle was investigated by in vitro functional studies and analysis of mRNA expression. Isoprenaline, noradrenaline and adrenaline each produced a concentration-dependent relaxation of the human detrusor. The rank...

Subject

Isoprenaline

Agonist

Chemistry

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