Significant Inhibition of Corneal Scarring In Vivo with Tissue-Selective, Targeted AAV5 Decorin Gene Therapy

R. Mohan, Rajiv; Tandon, Ashish; Sharma, Ajay; W. Cowden, John; Tovey, Jonathan

doi:10.1167/iovs.11-7357

Public

Significant Inhibition of Corneal Scarring In Vivo with Tissue-Selective, Targeted AAV5 Decorin Gene Therapy

Published in Investigative Ophthalmology & Visual Science • May 7, 2011

Authors:

Rajiv R. Mohan

Ashish Tandon

Ajay Sharma

Abstract

PURPOSE: This study tested a hypothesis that tissue-selective targeted decorin gene therapy delivered to the stroma with adeno-associated virus serotype 5 (AAV5) inhibits corneal fibrosis in vivo without significant side effects. METHODS: An in vivo rabbit model of corneal fibrosis was used. Targete...

Subject

Decorin

Cornea

Molecular biology

Research Assistant

AI chat, annotations, notes & similar papers

Finding related papers...

Discussions

(0)

No comments yet

Be the first to share your thoughts!