An Increased Percentage of Long Amyloid β Protein Secreted by Familial Amyloid β Protein Precursor (βApp <sub>717</sub> ) Mutants

Suzuki, Nobuhiro; T. Cheung, Tobun; Cai, Xiao-Dan; Odaka, Asano; Ötvös, László; B. Eckman, Christopher; E. Golde, Todd; G. Younkin, Steven

doi:10.1126/science.8191290

Public

An Increased Percentage of Long Amyloid β Protein Secreted by Familial Amyloid β Protein Precursor (βApp 717 ) Mutants

Published in Science • May 27, 1994

Authors:

Nobuhiro Suzuki

Tobun T. Cheung

Xiao-Dan Cai

Abstract

Normal processing of the amyloid beta protein precursor (beta APP) results in secretion of a soluble 4-kilodalton protein essentially identical to the amyloid beta protein (A beta) that forms insoluble fibrillar deposits in Alzheimer's disease. Human neuroblastoma (M17) cells transfected with constr...

Subject

BETA (programming language)

Cyanogen bromide

Amyloid precursor protein

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