TWIK1, a unique background channel with variable ion selectivity

C. Chatelain, Franck; Bichet, Delphine; Douguet, Dominique; Féliciangéli, Sylvain; Bendahhou, Saı̈d; Reichold, Markus; Warth, Richard; Barhanin, Jacques; Lesage, Florian

doi:10.1073/pnas.1201132109

Public

TWIK1, a unique background channel with variable ion selectivity

Published in Proceedings of the National Academy of Sciences • Mar 19, 2012

Authors:

Franck C. Chatelain

Delphine Bichet

Dominique Douguet

Abstract

TWIK1 belongs to the family of background K(+) channels with two pore domains. In native and transfected cells, TWIK1 is detected mainly in recycling endosomes. In principal cells in the kidney, TWIK1 gene inactivation leads to the loss of a nonselective cationic conductance, an unexpected effect th...

Subject

Depolarization

Selectivity

Biophysics

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