Vascular Endothelial Growth Factor Regulates Endothelial Cell Survival through the Phosphatidylinositol 3′-Kinase/Akt Signal Transduction Pathway

Gerber, Hans-Peter; E. McMurtrey, Amy; Kowalski, Joe; Yan, Minhong; A. Keyt, Bruce; M. Dixit, Vishva; Ferrara, Napoleone

doi:10.1074/jbc.273.46.30336

Public

Vascular Endothelial Growth Factor Regulates Endothelial Cell Survival through the Phosphatidylinositol 3′-Kinase/Akt Signal Transduction Pathway

Published in Journal of Biological Chemistry • Nov 1, 1998

Authors:

Hans-Peter Gerber

Amy E. McMurtrey

Joe Kowalski

Abstract

Vascular endothelial growth factor (VEGF) has been found to have various functions on endothelial cells, the most prominent of which is the induction of proliferation and differentiation. In this report we demonstrate that VEGF or a mutant, selectively binding to the Flk-1/KDR receptor, displayed hi...

Subject

Signal transduction

Phosphatidylinositol

Protein kinase B

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