Mutation of a <i>mutL</i> Homolog in Hereditary Colon Cancer

Papadopoulos, Nickolas; C. Nicolaides, Nicholas; Wei, Ying-Fei; M. Ruben, Steven; C. Carter, Kenneth; A Rosen, C; A. Haseltine, William; Fleischmann, Robert; M. Fraser, Claire; D. Adams, Mark; Craig Venter, J.; R. Hamilton, Stanley; M. Petersen, Gloria; Watson, Patrice; T. Lynch, Henry; Peltomäki, Païvi; Mecklin, Jukka‐Pekka; de la Chapelle, Albert; W. Kinzler, Kenneth; Vogelstein, Bert

doi:10.1126/science.8128251

Public

Mutation of a mutL Homolog in Hereditary Colon Cancer

Published in Science • Mar 18, 1994

Authors:

Nickolas Papadopoulos

Nicholas C. Nicolaides

Ying-Fei Wei

Abstract

Some cases of hereditary nonpolyposis colorectal cancer (HNPCC) are due to alterations in a mutS-related mismatch repair gene. A search of a large database of expressed sequence tags derived from random complementary DNA clones revealed three additional human mismatch repair genes, all related to th...

Subject

DNA mismatch repair

Genetics

Gene

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