Mutation of a mutL Homolog in Hereditary Colon Cancer

Papadopoulos, Nickolas; C. Nicolaides, Nicholas; Wei, Ying-Fei; M. Ruben, Steven; C. Carter, Kenneth; A Rosen, C; A. Haseltine, William; Fleischmann, Robert; M. Fraser, Claire; D. Adams, Mark; Craig Venter, J.; R. Hamilton, Stanley; M. Petersen, Gloria; Watson, Patrice; T. Lynch, Henry; Peltomäki, Païvi; Mecklin, Jukka‐Pekka; de la Chapelle, Albert; W. Kinzler, Kenneth; Vogelstein, Bert

doi:10.1126/science.8128251

Public

Mutation of a mutL Homolog in Hereditary Colon Cancer

Published in Science • Mar 18, 1994

Authors:

Nickolas Papadopoulos

Nicholas C. Nicolaides

Ying-Fei Wei

Abstract

Some cases of hereditary nonpolyposis colorectal cancer (HNPCC) are due to alterations in a mutS-related mismatch repair gene. A search of a large database of expressed sequence tags derived from random complementary DNA clones revealed three additional human mismatch repair genes, all related to th...

Subject

DNA mismatch repair

Genetics

Gene

Finding related papers...

Discussions

(0)

No comments yet

Be the first to share your thoughts!