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            -Mannosyl Phosphorylation of Alpha-Dystroglycan Is Required for Laminin Binding

Yoshida-Moriguchi, Takako; Yu, Liping; H. Stalnaker, Stephanie; Davis, Sarah; Kunz, Stefan; Madson, Michael; B. A. Oldstone, Michael; Schachter, Harry; Wells, Lance; P. Campbell, Kevin

doi:10.1126/science.1180512

Public

O -Mannosyl Phosphorylation of Alpha-Dystroglycan Is Required for Laminin Binding

Shared by NobleBlocks on Jan 1, 2010 • 12:00 AM UTC

Authors:

Takako Yoshida-Moriguchi

Liping Yu

Stephanie H. Stalnaker

Abstract

Modifying Protein Modification Alpha-dystroglycan (α-DG) is a cell-surface receptor that anchors the basal lamina to the sarcolemma by binding proteins containing laminin-G domains. This binding is essential for protecting muscle from contraction-induced injury, and defective binding is thought to c...

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