Long‐term survival and concomitant gene expression of ribozyme‐transduced CD4+ T‐lymphocytes in HIV‐infected patients

L. Macpherson, Janet; Boyd, Maureen; J Arndt, Allison; V. Todd, Alison; Fanning, Gregory; A. Ely, Julie; A Elliott, Fiona; E. Knop, Alison; Raponi, Mitch; M. Murray, John; L. Gerlach, Wayne; Sun, Lun‐Quan; Penny, Ronald; Symonds, Geoff; Carr, Andrew; A. Cooper, David

doi:10.1002/jgm.705

Public

Long‐term survival and concomitant gene expression of ribozyme‐transduced CD4+ T‐lymphocytes in HIV‐infected patients

Published in The Journal of Gene Medicine • Jan 17, 2005

Authors:

Janet L. Macpherson

Maureen Boyd

Allison J Arndt

Abstract

BACKGROUND: An anti-HIV-1 tat ribozyme, termed Rz2, has been shown to inhibit HIV-1 infection/replication and to decrease HIV-1-induced pathogenicity in T-lymphocyte cell lines and normal peripheral blood T-lymphocytes. We report here the results of a phase I gene transfer clinical trial using Rz2. ...

Subject

Biology

Ex vivo

Peripheral blood mononuclear cell

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