Intracellular Anions as the Voltage Sensor of Prestin, the Outer Hair Cell Motor Protein

Oliver, Dominik; Z. Z. He, David; Klöcker, Nikolaj; Ludwig, Jost; Schulte, Uwe; Waldegger, Siegfried; P. Ruppersberg, J.; Dallos, Peter; Fakler, Bernd

doi:10.1126/science.1060939

Public

Intracellular Anions as the Voltage Sensor of Prestin, the Outer Hair Cell Motor Protein

Published in Science • Jun 22, 2001

Authors:

Dominik Oliver

David Z. Z. He

Nikolaj Klöcker

Abstract

Outer hair cells (OHCs) of the mammalian cochlea actively change their cell length in response to changes in membrane potential. This electromotility, thought to be the basis of cochlear amplification, is mediated by a voltage-sensitive motor molecule recently identified as the membrane protein pres...

Subject

Prestin

Intracellular

Motor protein

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