Tregs prevent GVHD and promote immune reconstitution in HLA-haploidentical transplantation

Di Ianni, Mauro; Falzetti, Franca; Carotti, Alessandra; Terenzi, Adelmo; Castellino, Flora; Bonifacio, Elisabetta; Del Papa, Beatrice; Zei, Tiziana; Iacucci Ostini, Roberta; Cecchini, Debora; Aloisi, Teresa; Perruccio, Katia; Ruggeri, Loredana; Balucani, Chiara; Pierini, Antonio; Sportoletti, Paolo; Aristei, Cynthia; Falini, Brunangelo; Reisner, Yaīr; Velardi, Andrea; Aversa, Franco; F. Martelli, Massimo

doi:10.1182/blood-2010-10-311894

Public

Tregs prevent GVHD and promote immune reconstitution in HLA-haploidentical transplantation

Published in Blood • Feb 3, 2011

Authors:

Mauro Di Ianni

Franca Falzetti

Alessandra Carotti

Abstract

Hastening posttransplantation immune reconstitution is a key challenge in human leukocyte antigen (HLA)-haploidentical hematopoietic stem-cell transplantation (HSCT). In experimental models of mismatched HSCT, T-regulatory cells (Tregs) when co-infused with conventional T cells (Tcons) favored postt...

Subject

Immunology

Immunosuppression

Human leukocyte antigen

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