Stepwise Development of MAIT Cells in Mouse and Human

Martin, Emmanuel; Treiner, Emmanuel; Duban, Livine; Guerri, Lucía; Laude, Hélène; Toly, Cécile; Prémel, Virginie; Devys, Anne; Cruz Moura, Ivan; Tilloy, Florence; Cherif, Stéphane; Vera, Gabriella; Latour, Sylvain; Soudais, Claire; Lantz, Olivier

doi:10.1371/journal.pbio.1000054

Public

Stepwise Development of MAIT Cells in Mouse and Human

Published in PLoS Biology • Mar 6, 2009

Authors:

Emmanuel Martin

Emmanuel Treiner

Livine Duban

Abstract

Mucosal-associated invariant T (MAIT) cells display two evolutionarily conserved features: an invariant T cell receptor (TCR)alpha (iTCRalpha) chain and restriction by the nonpolymorphic class Ib major histocompatibility complex (MHC) molecule, MHC-related molecule 1 (MR1). MR1 expression on thymus ...

Subject

Biology

Natural killer T cell

T-cell receptor

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