Role of IKur in controlling action potential shape and contractility in the human atrium: influence of chronic atrial fibrillation.

E, Wettwer; O, Hála; T, Christ; JF, Heubach; D, Dobrev; M, Knaut; A, Varró; U, Ravens

doi:10.1161/01.cir.0000145155.60288.71

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Role of IKur in controlling action potential shape and contractility in the human atrium: influence of chronic atrial fibrillation.

Shared by NobleBlocks on Oct 11, 2004 • 12:00 AM UTC

Authors:

Wettwer E

Hála O

Christ T

Abstract

Background The ultrarapid outward current I(Kur) is a major repolarizing current in human atrium and a potential target for treating atrial arrhythmias. The effects of selective block of I(Kur) by low concentrations of 4-aminopyridine or the biphenyl derivative AVE 0118 were investigated on right at...

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