IRF4 Transcription Factor-Dependent CD11b+ Dendritic Cells in Human and Mouse Control Mucosal IL-17 Cytokine Responses

Schlitzer, Andreas; McGovern, Naomi; Teo, Pearline; Zelante, Teresa; Atarashi, Koji; Low, Donovan; W. S. Ho, Adrian; See, Peter; Shin, Amanda; Singh Wasan, Pavandip; Hoeffel, Guillaume; Malleret, Benoît; Heiseke, Alexander; Chew, Samantha; Jardine, Laura; A. Purvis, Harriet; M. U. Hilkens, Catharien; Kit Chung Tam, John; Poidinger, Michael; Richard Stanley, E.; Krug, Anne; Rénia, Laurent; Sivasankar, Baalasubramanian; Guan Ng, Lai; Collin, Matthew; Ricciardi‐Castagnoli, Paola; Honda, Kenya; Haniffa, Muzlifah; Ginhoux, Florent

doi:10.1016/j.immuni.2013.04.011

Public

IRF4 Transcription Factor-Dependent CD11b+ Dendritic Cells in Human and Mouse Control Mucosal IL-17 Cytokine Responses

Published in Immunity • May 1, 2013

Authors:

Andreas Schlitzer

Naomi McGovern

Pearline Teo

Abstract

Mouse and human dendritic cells (DCs) are composed of functionally specialized subsets, but precise interspecies correlation is currently incomplete. Here, we showed that murine lung and gut lamina propria CD11b+ DC populations were comprised of two subsets: FLT3- and IRF4-dependent CD24(+)CD64(-) D...

Subject

IRF4

Biology

Immunology

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