Dose-response relation between terfenadine (Seldane) and the QTc interval on the scalar electrocardiogram: distinguishing a drug effect from spontaneous variability.

M Pratt, C; Ruberg, S; Morganroth, J; McNutt, B; Woodward, J; Harris, S; Ruskin, J; Moye, L

doi:10.1016/s0002-8703(96)90525-6

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Dose-response relation between terfenadine (Seldane) and the QTc interval on the scalar electrocardiogram: distinguishing a drug effect from spontaneous variability.

Published in American heart journal • Mar 1, 1996

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Authors:

C M Pratt

,

S Ruberg

,

J Morganroth

Abstract

The primary goal of this investigation was to describe the effect of terfenadine on the QT interval corrected for heart rate (QTc) of the scalar electrocardiogram (ECG). The design was double-blind, four-period crossover, dose escalation, which involved 28 normal healthy volunteers and 28 patients w...

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