Positive Effects of Combined Antiretroviral Therapy on CD4 + T Cell Homeostasis and Function in Advanced HIV Disease

Autran, Brigitte; Carcelain, Guislaine; S. Li, T.; Blanc, Catherine; Mathez, Dominique; Tubiana, Roland; Katlama, Christine; Debré, Patrice; Leibowitch, Jacques

doi:10.1126/science.277.5322.112

Public

Positive Effects of Combined Antiretroviral Therapy on CD4 + T Cell Homeostasis and Function in Advanced HIV Disease

Published in Science • Jul 4, 1997

Authors:

Brigitte Autran

Guislaine Carcelain

T. S. Li

Abstract

Highly active antiretroviral therapy (HAART) increases CD4(+) cell numbers, but its ability to correct the human immunodeficiency virus (HIV)-induced immune deficiency remains unknown. A three-phase T cell reconstitution was demonstrated after HAART, with: (i) an early rise of memory CD4(+) cells, (...

Subject

Antiretroviral therapy

CD8

Immunology

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