Pembrolizumab for the Treatment of Non–Small-Cell Lung Cancer

B. Garon, Edward; A. Rizvi, Naiyer; Hui, Rina; B. Leighl, Natasha; Sarkis Balmanoukian, Ani; P. Eder, Joseph; Patnaik, Amita; Aggarwal, Charu; A. Gubens, Matthew; Horn, Leora; Carcereny, Enric; Ahn, Myung‐Ju; Felip, Enriqueta; Lee, Jong-Seok; D. Hellmann, Matthew; Hamid, Omid; W. Goldman, Jonathan; Soria, Jean‐Charles; Dolled‐Filhart, Marisa; Z. Rutledge, Ruth; Zhang, Jin; Lunceford, Jared; Rangwala, Reshma; M. Lubiniecki, Gregory; Roach, Charlotte; Emancipator, Kenneth; Gandhi, Leena

doi:10.1056/nejmoa1501824

Public

Pembrolizumab for the Treatment of Non–Small-Cell Lung Cancer

Published in New England Journal of Medicine • Apr 19, 2015

Authors:

Edward B. Garon

Naiyer A. Rizvi

Rina Hui

Abstract

BACKGROUND: We assessed the efficacy and safety of programmed cell death 1 (PD-1) inhibition with pembrolizumab in patients with advanced non-small-cell lung cancer enrolled in a phase 1 study. We also sought to define and validate an expression level of the PD-1 ligand 1 (PD-L1) that is associated ...

Subject

Pembrolizumab

Medicine

Lung cancer

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