Novel Benzodioxan Derivative, 5-{3-[((2S)-1,4-Benzodioxan-2-ylmethyl)amino]propoxy}-l,3-benzodioxole HC1 (MKC-242), with a Highly Potent and Selective Agonist Activity at Rat Central Serotonin1A Receptors

Matsuda, Toshio; Yoshikawa, Takashi; Suzuki, Makoto; Asano, Shoichi; Somboonthum, Pranee; Takuma, Kazuhiro; Nakano, Yoshihide; Morita, Tomoko; Nakasu, Yukiko; Sun Kim, Hye; Egawa, Mitsuo; Tobe, Akihiro; Baba, Akemichi

doi:10.1254/jjp.69.357

Public

Novel Benzodioxan Derivative, 5-{3-[((2S)-1,4-Benzodioxan-2-ylmethyl)amino]propoxy}-l,3-benzodioxole HC1 (MKC-242), with a Highly Potent and Selective Agonist Activity at Rat Central Serotonin1A Receptors

Published in The Japanese Journal of Pharmacology • Jan 1, 1995

Authors:

Toshio Matsuda

Takashi Yoshikawa

Makoto Suzuki

Abstract

The present study characterizes the neurochemical profile of the newly synthesized compound 5-(3-[((2S)-1,4-benzodioxan-2-ylmethyl)amino]propoxy)-1,3-be nzodioxole HCl (MKC-242). In in vitro experiments, MKC-242 had high affinity for serotonin1A (5-HT1A) receptors (Ki: 0.35 nM) and moderate affinity...

Subject

Agonist

5-HT1A receptor

Postsynaptic potential

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