Differentiation syndrome in patients with acute promyelocytic leukemia treated with all-trans retinoic acid and anthracycline chemotherapy: characteristics, outcome, and prognostic factors

Montesinos, Pau; Bergua, Juan; Vellenga, Edo; Rayón, Chelo; Parody, Ricardo; de la Serna, Javier; León, Ángel; Esteve, Jordi; Milone, Giuseppe; Debén, Guillermo; Rivas, Concha; González, Marcos; Tormo, Mar; Diaz‐Mediavilla, Joaquín; D. González, José; Negri, Silvia; Amutio, Elena; Brunet, Salut; Löwenberg, Bob; Á. Sanz, Miguel

doi:10.1182/blood-2008-07-168617

Public

Differentiation syndrome in patients with acute promyelocytic leukemia treated with all-trans retinoic acid and anthracycline chemotherapy: characteristics, outcome, and prognostic factors

Published in Blood • Oct 22, 2008

Authors:

Pau Montesinos

Juan Bergua

Edo Vellenga

Abstract

Differentiation syndrome (DS) can be a life-threatening complication in patients with acute promyelocytic leukemia (APL) undergoing induction therapy with all-trans retinoic acid (ATRA). Detailed knowledge about DS has remained limited. We present an analysis of the incidence, characteristics, progn...

Subject

Acute promyelocytic leukemia

Anthracycline

Chemotherapy

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