Demonstrated brain insulin resistance in Alzheimer’s disease patients is associated with IGF-1 resistance, IRS-1 dysregulation, and cognitive decline

Talbot, Konrad; Wang, Hoau-Yan; Kazi, Hala; Han, Liying; Bakshi, Kalindi; Stucky, Andres; L. Fuino, Robert; R. Kawaguchi, Krista; Samoyedny, Andrew; S. Wilson, Robert; Arvanitakis, Zoe; A. Schneider, Julie; A. Wolf, Bryan; A. Bennett, David; Q. Trojanowski, John; E. Arnold, Steven

doi:10.1172/jci59903

Public

Demonstrated brain insulin resistance in Alzheimer’s disease patients is associated with IGF-1 resistance, IRS-1 dysregulation, and cognitive decline

Published in Journal of Clinical Investigation • Mar 27, 2012

Authors:

Konrad Talbot

Hoau-Yan Wang

Hala Kazi

Abstract

While a potential causal factor in Alzheimer's disease (AD), brain insulin resistance has not been demonstrated directly in that disorder. We provide such a demonstration here by showing that the hippocampal formation (HF) and, to a lesser degree, the cerebellar cortex in AD cases without diabetes e...

Subject

Insulin resistance

Insulin receptor

Endocrinology

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