Susceptibility to antivirals of a human HBV strain with mutations conferring resistance to both lamivudine and adefovir†

Brunelle, Marie‐Noëlle; Jacquard, Anne‐Carole; Pichoud, Christian; Durantel, David; Carrouée‐Durantel, Sandra; Villeneuve, Jean‐Pierre; Trépo, Christian; Zoulim, Fabien

doi:10.1002/hep.20723

Public

Susceptibility to antivirals of a human HBV strain with mutations conferring resistance to both lamivudine and adefovir†

Published in Hepatology • May 24, 2005

Authors:

Marie‐Noëlle Brunelle

Anne‐Carole Jacquard

Christian Pichoud

Abstract

Mutations within the hepatitis B virus (HBV) polymerase gene conferring drug-resistance are selected during prolonged lamivudine (3TC) or adefovir dipivoxil (ADV) treatment. Because there is no other approved drug against HBV, treatments with 3TC or ADV are used either sequentially or in addition, d...

Subject

Adefovir

Lamivudine

Virology

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