Epigenetic Control of the foxp3 Locus in Regulatory T Cells

Floess, Stefan; Freyer, Jennifer; Siewert, Christiane; Baron, Udo; Olek, Sven; K. Polansky, Julia; Schlawe, Kerstin; Chang, Hyun‐Dong; Bopp, Tobias; Schmitt, Edgar; Klein‐Hessling, Stefan; Serfling, Edgar; Hamann, Alf; Huehn, Jochen

doi:10.1371/journal.pbio.0050038

Public

Epigenetic Control of the foxp3 Locus in Regulatory T Cells

Published in PLoS Biology • Jan 26, 2007

Authors:

Stefan Floess

Jennifer Freyer

Christiane Siewert

Abstract

Compelling evidence suggests that the transcription factor Foxp3 acts as a master switch governing the development and function of CD4(+) regulatory T cells (Tregs). However, whether transcriptional control of Foxp3 expression itself contributes to the development of a stable Treg lineage has thus f...

Subject

FOXP3

Biology

Epigenetics

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